ncRNA basic information
ncRNA ID:
MI0003124
ncRNA Database:
miRBase
ncRNA Name:
miR-489
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
Akt3
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by quantitative real-time RT-PCR (qRT-PCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
ovarian cancer
Tissue/Cell:
cell line ( SKOV3, OVCAR3, SKOV3/CDDP, OVCAR3/CDDP)
Other information
Title:
MiR-489 modulates cisplatin resistance in human ovarian cancer cells by targeting Akt3.
Journal:
Anticancer Drugs
Published:
2014
PubMed ID:
24686007