ncRNA basic information
ncRNA ID:
MI0000446/MI0000470
ncRNA Database:
miRBase
ncRNA Name:
miR-125b
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
Bak1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00853 (APRD00557)
Drug Name:
Temozolomide
Drug Method:
The role of miR-125b in glioblastoma stem cells was detected using oligonucleotide transfection, RT-PCR, cell viability assay, cell cycle analysis, western blot, luciferase targeting assay, in vivo tumor model, etc.
Drug Response:
resistant
Cancer basic information
Cancer:
glioblastoma
Tissue/Cell:
tissue and cell line ( CD133/1,CD133/2-PE)
Other information
Title:
miR-125b inhibitor enhance the chemosensitivity of glioblastoma stem cells to temozolomide by targeting Bak1.
Journal:
Tumour Biol
Published:
2014
PubMed ID:
24643683