ncRNA basic information
ncRNA ID:
MI0000650
ncRNA Database:
miRBase
ncRNA Name:
miR-200c
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
ZNF217 and ZEB1
ncRNA Pathway:
TGF-Beta/ZEB1 signaling
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00072 (BTD00098, BIOD00098)
Drug Name:
Trastuzumab
Drug Method:
The role of miR-200c in breast cancer cells was detected using Quantitative RT-PCR, plasmid construction, preparation of lentivirus, MTT assay and soft agar colony formation assay, apoptosis assay, wound healing assay, matrigel invasion analysis, western blot analysis, construction of ZEB1 and ZNF217 untranslated region luciferase plasmids and reporter assay, etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (SKBr-3)
Other information
Title:
MiR-200c suppresses TGF-Beta signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer.
Journal:
Int J Cancer
Published:
2014
PubMed ID:
24615544