ncRNA basic information
ncRNA ID:
MI0000077
ncRNA Database:
miRBase
ncRNA Name:
miR-21
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
PCR
ncRNA Target Gene:
BCL2
ncRNA Pathway:
c-Jun signaling
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The role of miR-21 in breast cancer cells was detected using chromatin immunoprecipitation assay, immunofluorescence staining, tumor cell growth and apoptosis assays, etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MDA-MB-468)
Other information
Title:
Hyaluronan-CD44 interaction promotes c-Jun signaling and miRNA21 expression leading to Bcl-2 expression and chemoresistance in breast cancer cells.
Journal:
Mol Cancer
Published:
2014
PubMed ID:
24606718