ncRNA basic information
ncRNA ID:
MI0000446/MI0000470
ncRNA Database:
miRBase
ncRNA Name:
miR-125b
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qPCR
ncRNA Target Gene:
GRK2 and PUMA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00694 (APRD00521)
Drug Name:
Daunorubicin
Drug Method:
The expression levels of miRNA were determined by quantitative polymerase chain reaction (qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
leukemia
Tissue/Cell:
cell line (K562, THP-1, Jurkat, REH,HEK293T )
Other information
Title:
microRNA-125b promotes leukemia cell resistance to daunorubicin by inhibiting apoptosis.
Journal:
Mol Med Rep
Published:
2014
PubMed ID:
24604579