ncRNA basic information
ncRNA ID:
MI0000442
ncRNA Database:
miRBase
ncRNA Name:
miR-122
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
Real-time RT-PCR,Semiquantitative RT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
p53 signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The expression levels of miRNA were determined byReal-time RT-PCR analysis and Semiquantitative RT-PCR.Those of protein were by Western blot analysis. p53 activity was investigated by luciferase assay
Drug Response:
sensitive
Cancer basic information
Cancer:
hepatocarcinoma
Tissue/Cell:
cell line (HepG2,Huh-7)
Other information
Title:
MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells.
Journal:
Cancer Res
Published:
2009
PubMed ID:
19584283