ncRNA basic information
ncRNA ID:
MI0003188
ncRNA Database:
miRBase
ncRNA Name:
miR-503
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
real time RT-PCR
ncRNA Target Gene:
FANCA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
In the present study, the level of miR-503 expression in NSCLC was evaluated using realtime PCR, and the DNA methylation status within miR-503 promoter was analyzed by Combined Bisulfite Restriction Analysis (COBRA) or bisulfite-treated DNA sequencing assays (BSP). Luciferase activity assay was used to verify the target genes of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
lung non-small cell carcinoma
Tissue/Cell:
cell line (A549,H466,H1650,H1299,A549/cis)
Other information
Title:
Epigenetic silencing of MicroRNA-503 regulates FANCA expression in non-small cell lung cancer cell.
Journal:
Biochem Biophys Res Commun
Published:
2014
PubMed ID:
24486548